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Ligand-specific activation trajectories dictate GPCR signalling in cells - Nature
Different agonists produce equilibria of at least four distinct active states of the G-protein-bound M2 muscarinic acetylcholine receptor, each with a different ability to activate G proteins.
"I'm not afraid of risk" - A newly independent GOG eyes indie game publishing, something it couldn't do under CD Projekt Red - Eurogamer
Newly independent PC digital game shop GOG is interested in getting into publishing indie games - something it apparent…
Direct observation of the Migdal effect induced by neutron bombardment - Nature
Direct observation of the Migdal effect in neutron–nucleus collisions is reported, which resolves a long-standing gap in experimental validation.
Will Apple Announce New MacBook Pros This January? - MacRumors
While the entry-level 14-inch MacBook Pro was updated with an M5 chip in October, we are still waiting for higher-end MacBook Pro models with M5 Pro...
I TRULY Was Not Prepared For How Hard I Cackled At These Random People Who Dropped The Funniest Replies Out Of Nowhere - BuzzFeed
Absolutely nailed it.
Umamusume developer apologises after AI studio backlash, says it will not use generative AI "without prior notice" - Eurogamer
Gemini's new beta feature provides proactive responses based on your photos, emails, and more - TechCrunch
Personal Intelligence is off by default, as users have the option to choose if and when they want to connect their Google apps to Gemini.
Ubisoft confirms 29 jobs lost at Abu Dhabi mobile studio - GamesIndustry.biz
Animal Crossing: New Horizons Update 3.0 Is Live Now, A Day Early - Game Informer
While version 3.0 is live now, islanders will have to wait another day for the Switch 2 upgrade to wash to shore.
Animal Crossing’s big 3.0 update has fans itching to return to the cozy life - The Verge
With its 3.0 update and Switch 2 upgrade, Animal Crossing: New Horizons is primed to bring many players back to the game.
Microsoft might have just leaked Forza Horizon 6’s release date - The Verge
A May 19th release date has appeared inside a Forza Horizon 5 notification.
String Theory Can Now Describe a Universe That Has Dark Energy - Quanta Magazine
In an unprecedented step, researchers crafted a detailed model compatible with the universe’s accelerated expansion.
The new $1,100 2026 Lenovo business laptop is on sale for $400 at Amazon - thestreet.com
This laptop can handle multitasking spreadsheets, research tabs, and more.
10 Soundbars You Need To Replace Your TV Audio With, According To Experts - bgr.com
Ultra-thin televisions look great and save tons of space, but tend to suffer when it comes to audio. These soundbars can help take it to the next level.
Meet The New Ford New Mustang Dark Horse SC - Motor1.com
We get an early look at the new Mustang Dark Horse SC with a Formula 1 pro behind the wheel. Watch the full video.
SparkFun Officially Dropping AdaFruit due to CoC Violation - Hacker News
Someone’s Galaxy Z TriFold display already spontaneously broke - 9to5Google
Samsung’s new Galaxy Z TriFold looks incredible – all the more so in person – but also came with the...
Calling all home cinema fans! The Award-winning Marantz AVR is on sale - What Hi-Fi?
Who wants £500 off a hugely talented AVR?
Peakto 2.6 Tracks Down All Your Duplicate Photos, No Matter Where They Are - PetaPixel
Find all those pesky duplicate photos in seconds.
A little bubbly brings out the best in a bloom - The Seattle Times
This week's Reader's Lens photographer shares how an effervescent-blur effect highlights a flower's beautiful details.